A large number of the projects undertaken by the Pritzker Consortium rely on the high-quality tissue provided by the UC Irvine Brain Bank. The Brain Bank collects brains from schizophrenic, major depressive disorder, bipolar disorder subjects and controls. The Psychological Autopsy team conducts thorough clinical characterizations of cases using a 142-item protocol. Members of the Brain Bank conduct rigorous evaluation of brain tissue quality including pH and gross and microscopic neuropathological examination. Matched cohorts of rigorously characterized brains are developed. Samples from specific regions of brain, identified during carefully controlled dissection at UC Irvine, are distributed to the Pritzker Consortium scientists for ongoing investigations.

Brain Dissection

Brains are dissected at UC Irvine into various brain regions by Consortium members and barcoded for tracking purposes. The RNA and DNA are extracted from various brain regions and frozen for further studies. The tissue and samples are made available to all Consortium members for gene expression and genotyping/methylation studies. Non-human primate brains are also available for neuroanatomical comparison studies.

Brain regions for dissection in depressive, schizophrenic and control cohorts

Image showing brain regions sampled
  1. Frontal Pole
  2. Dorsolateral Prefrontal Cortex
  3. Medial Prefrontal Cortex
  4. Orbitofrontal Cortex
  5. Superior Temporal Gyrus
  6. Hippocampus
  7. Entorhinal Cortex
  8. Anterior Cingulate
  9. Subgenual Cingulate
  10. Amygdala
  11. Substantial Nigra
  12. Globus Pallidus
  13. Putamen
  14. Caudate
  15. Thalamus (Mediodorsal, Nucleus, Anterior Nucleus)
  16. Nucleus Accumbens
  17. Dorsal Raphe
  18. Cerebellum
  19. Occiptal Cortex
  20. Suprachiasmatic Nucleus
  21. Parietal Cortex
  22. Locus Coeruleus