COMPARISON OF GENE EXPRESSION PROFILES BETWEEN BIPOLAR DISORDER, MAJOR DEPRESSION AND SCHIZOPHRENIA IN CORTICAL BRAIN REGIONS.
S.J. Evans; M.P. Vawter; P.V. Choudary; J. Li; H. Tomita; M. Atz; J.F. Lopez; R.C. Thompson; B.M. Bolstad; T.P. Speed; R.M. Myers,; W.E. Bunney; E.G. Jones; S.J. Watson; H. Akil
Society for Neuroscience 33rd Annual Meeting. 2003.
We have used Affymetrix Gene Chip technology to evaluate several discrete brain structures implicated in bipolar disorder (BPD), major depressive disorder (MDD) and/or schizophrenia (SZ). Brain regions analyzed in all three disorders include dorsal lateral prefrontal cortex (DLPFC), anterior cingulated cortex (AnCg) and cerebellar cortex (CB). To support microarray findings we have also utilized serial analysis of gene expression (SAGE), real-time PCR (RT-PCR) and in situ hybridization (ISH) techniques. In this report we will discuss common aspects of apparent gene misregulation across the afore-mentioned disorders. We will focus on specific genes that show patterns of misregulation and discuss ontological families, and biochemical and signaling pathways that may contribute to the pathology, expression and maintenance of these diseases. Support Contributed By: This work was supported by the Pritzker Neuropsychiatric Disorder Research Consortium Fund and NIH Conte grant MH60398-03. We acknowledge participation of all consortium members in this work.