PATHOLOGY OF SCHIZOPHRENIA
Society for Neuroscience 33rd Annual Meeting. 2003.
Despite the prevalence of schizophrenia and the profound social and economic consequences accompanying it, the underlying pathology remains enigmatic. In the last two or three decades, structural and functional imaging studies have raised the likelihood that symptoms can be interpreted in terms of a functional disconnection. Now, high throughput gene expression studies begin to reveal alterations that bespeak disturbances of synaptic connectivity, neuronal signaling and transmitter metabolism which, when combined with linkage studies, point to a range of genes that confer susceptibility to schizophrenia.