Consortium Publications
- Daily rhythms drive dynamism in sleep, oscillations and interneuron firing, while excitatory firing remains stable across 24 h
Ognjanovski N, Kim DS, Charlett-Green E, Goldiez E, van Koppen S, Aton SJ, Watson BO
Eur J Neurosci. 2025; 61(1):e16619. - Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia
Martínez-Rivera A, Fetcho RN, Birmingham L, Xu J, Yang R, Foord C, Scala-Chávez D, Mekawy N, Pleil K, Pickel VM, Liston C, Castorena CM, Levitz J, Pan YX, Briand LA, Rajadhyaksha AM, Lee FS
Sci Adv. 2024; 10(48):eadq4779. - Three-dimensional-printed headcap with embedded microdrive system for customizable multi-region brain recordings with neural probes
Hartner JD, Yi D, Zhu HL, Watson BO, Chen L
Front Neurosci. 2024; 18:1478421. - Allele-specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs
Anderson AG, Moyers BA, Loupe JM, Rodriguez-Nunez I, Felker S, Lawlor JMJ, Bunney WE, Bunney BG, Cartagena PM, Sequeira A, Watson SJ, Akil H, Mendenhall EM, Cooper GM, Myers RM
Genome Res. 2024; 34(8):1224-1234. - Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial
Bress JN, Falk A, Schier MM, Jaywant A, Moroney E, Dargis M, Bennett SM, Scult MA, Volpp KG, Asch DA, Balachandran M, Perlis RH, Lee FS, Gunning FM
JAMA Netw Open. 2024; 7(8):e2428372. - Multiomic profiling of transcription factor binding and function in human brain
Loupe JM, Anderson AG, Rizzardi LF, Rodriguez-Nunez I, Moyers BA, Trausch-Lowther K, Rashmi J, Bunney WE, Bunney BG, Cartagena PM, Sequeira A, Watsons SJ, Akil H, Cooper GM, Myers RM
Nat Neurosci. 2024; 27(7):1387-1399. - Resource: A curated database of brain-related functional gene sets (Brain.GMT)
Hagenauer MH, Sannah Y, Hebda-Bauer EK, Rhoads C, O'Connor AM, Flandreau E, Watson SJ, Akil H
MethodsX. 2024; 13:102788. - Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype
O'Connor AM, Hagenauer MH, Thew Forrester LC, Maras PM, Arakawa K, Hebda-Bauer EK, Khalil H, Richardson ER, Rob FI, Sannah Y, Watson SJ, Akil H
Neurobiol Stress. 2024; 31:100651. - Proteomic profiles of cytokines and chemokines in moderate to severe depression: Implications for comorbidities and biomarker discovery
Watson KT, Keller J, Spiro CM, Satz IB, Goncalves SV, Pankow H, Kosti I, Lehallier B, Sequeira A, Bunney WE, Rasgon NL, Schatzberg AF
Brain Behav Immun Health. 2024; 36:100731. - Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
Lao-Peregrin C, Xiang G, Kim J, Srivastava I, Fall AB, Gerhard DM, Kohtala P, Kim D, Song M, Garcia-Marcos M, Levitz J, Lee FS
Cell Rep. 2024; 3(1):113595. - The role of neurotrophic factors in novel, rapid psychiatric treatments
Kim J, He MJ, Widmann AK, Lee FS
Neuropsychopharmacology. 2024; 49(1):227-245. - The role of neurotrophic factors in novel, rapid psychiatric treatments
Kim JH, He MJ, Widmann AK, Lee FS
Neuropsychopharmacology. 2024; 49(1):227-245. - Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
Lao-Peregrin C, Xiang GQ, Kim JH, Srivastava I, Fall AB, Gerhard DM, Kohtala P, Kim DG, Song MS, Garcia-Marcos M, Levitz J, Lee FS
Cell Rep. 2024; 43(1):113595. - The why, when, where, how, and so what of so-called rapidly acting antidepressants
Schatzberg AF, Mathew SJ
Neuropsychopharmacology. 2024; 49(1):189-196. - Cell-Type Specific Reductions in Interneuron Gene Expression within Subregions of the Anterior and Posterior Cingulate Gyrus of Schizophrenia and Bipolar Disorder Subjects
Krolewski DM, Waselus M, Bunney BG, Myers RM, Barchas JD, Lee FS, Schatzberg AF, Bunney WE, Akil H, Watson SJ
bioRxiv. 2024. - Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs
Moyers BA, Loupe JM, Felker SA, Lawlor JMJ, Anderson AG, Rodriguez-Nunez I, Bunney WE, Bunney BG, Cartagena PM, Sequeira A, Watson SJ, Akil H, Mendenhall EM, Cooper GM, Myers RM
bioRxiv. 2023. - Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships
Fetcho RN, Hall BS, Estrin DJ, Walsh AP, Schuette PJ, Kaminsky J, Singh A, Roshgodal J, Bavley CC, Nadkarni V, Antigua S, Huynh TN, Grosenick L, Carthy C, Komer L, Adhikari A, Lee FS, Rajadhyaksha AM, Liston C
Nat Commun. 2023; 14(1):2487. - Translating developmental neuroscience to understand risk for psychiatric disorders
Meyer HC, Lee FS
Am J Psychiatry. 2023; 180(8):540-547. - Intermixed safety cues facilitate extinction retention in adult and adolescent mice
Meyer HC, Lee FS
Physiol Behav. 2023; 271:114336. - Toward a Precision Treatment Approach for Metabolic Depression: Integrating Epidemiology, Neuroscience, and Psychiatry
Watson K, Akil H, Rasgon N
Biol Psychiatry Glob Open Sci. 2023; 3(4):623-631. - The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans
Bueno-Junior LS, Ruckstuhl MS, Lim MM, Watson BO
Proc Natl Acad Sci USA. 2023; 120(18):e221343812. - High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor
Wei Q, Kumar V, Moore S, Li F, Murphy GG, Watson SJ, Akil H
Neurobiol Stress. 2023; 27:100581. - The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress
Turner CA, Khalil H, Murphy-Weinberg V, Hagenauer MH, Gates L, Tang Y, Weinberg L, Grysko R, Floran-Garduno L, Dokas T, Samaniego C, Zhao Zhuo, Fang Y, Sen S, Lopez JF, Watson SJ, Akil H
Proc Natl Acad Sci USA. 2023; 120(49):e2305779120. - Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia
Medina AM, Hagenauer MH, Krolewski DM, Hughes E, Forrester LC, Walsh DM, Waselus M, Richardson E, Turner CA, Sequeira PA, Cartagena PM, Thompson RC, Vawter MP, Bunney BG, Myers RM, Barchas JD, Lee FS, Schatzberg AF, Bunney WE, Akil H, Watson SJ
Transl Psychiatry. 2023; 13(1):118. - Ecological validity of social defeat stressors in mouse models of vulnerability and resilience
Lyons DM, Ayash S, Schatzberg AF, Müller MB
Neurosci Biobehav Rev. 2023; 145:105032. - Large Common Mitochondrial DNA Deletions Are Associated with a Mitochondrial SNP T14798C Near the 3' Breakpoints
Hjelm BE, Ramiro C, Rollins BL, Omidsalar AA, Gerke DS, Das SC, Sequeira A, Morgan L, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Bunnery WE, Vawter MP
Complex Psychiatry. 2023; 8(3-4):90-98. - Blood-based biomarkers for suicide in depression: moving a step closer to prediction
Mamdani F, Sequeira A
Neuropsychopharmacology. 2023; 48:245-246. - Control of Gαq signaling dynamics and GPCR cross-talk by GRKs
Xiang G, Acosta-Ruiz A, Radoux-Mergault A, Kristt M, Kim J, Moon JD, Broichhagen J, Inoue A, Lee FS, Stoeber M, Dittman JS, Levitz J
Sci Adv. 2022; 8(47):eabq3363. - Forebrain glucocorticoid receptor overexpression alters behavioral encoding of hippocampal CA1 pyramidal cells in mice
Gavade S, Wei Q, Johnston C, Kounelis-Wuillaume S, Laborc K, Baranwal S, Akil H, Spencer-Segal JL
eNeuro. 2022; 9(6):ENEURO.0126-22. - Overexpression of cancer- and neurotransmitter-associated genes in the nucleus accumbens of smokers
Stein R, Mamdani F, Bunney B, Cartagena P, Vawter MP, Schatzberg AF, Barchas J, Lee FS, Myers R, Watson SJ, Akil H, Bunney WE, Sequeira A
Epub ahead of print. 2022. - Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression
Talishinsky A, Downar J, Vértes PE, Seidlitz J, Dunlop K, Lynch CJ, Whalley H, McIntosh A, Vila-Rodriguez F, Daskalakis ZJ, Blumberger DM, Liston C
Nat Commun. 2022; 13(1):5692. - Neurotransmission-related gene expression in the frontal pole (Brodmann Area 10) is altered in subjects with bipolar disorder and schizophrenia
Medina AM, Hagenauer MH, Krolewski DM, Hughes E, Forrester LCT, Walsh DM, Waselus M, Richardson E, Turner CA, Sequiera PA, Preston Cartagena P, Thompson RC, Vawter MP, Bunney BG, Myers RM, Barchas JD, Lee, FSY, Schatzberg AF, Bunney WE, Huda Akil A, Watson SJ
Transl Psychiatry. 2022; Epub ahead of print. - Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder
Das SC, Hjelm BE, Rollins BL, Sequeira A, Morgan L, Omidsalar AA, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Bunney WE, Vawter MP
Transl Psychiatry. 2022; 12(1):353. - Rare coding variants in ten genes confer substantial risk for schizophrenia
Singh T, Poterba T, Curtis D, Akil H, Al Eissa M, Barchas JD, Bass N, Bigdeli TB, Breen G, Bromet EJ, Buckley PF, Bunney WE, Bybjerg-Grauholm J, Byerley WF, Chapman SB, Chen WJ, Churchhouse C, Craddock N, Cusick CM, DeLisi L, Dodge S, Escamilla MA, Eskelinen S, Fanous AH, Faraone SV, Fiorentino A, Francioli L, Gabriel SB, Gage D, Gagliano Taliun SA, Ganna A, Genovese G, Glahn DC, Grove J, Hall MH, Hämäläinen E, Heyne HO, Holi M, Hougaard DM, Howrigan DP, Huang H, Hwu HG, Kahn RS, Kang HM, Karczewski KJ, Kirov G, Knowles JA, Lee FS, Lehrer DS, Lescai F, Malaspina D, Marder SR, McCarroll SA, McIntosh AM, Medeiros H, Milani L, Morley CP, Morris DW, Mortensen PB, Myers RM, Nordentoft M, O'Brien NL, Olivares AM, Ongur D, Ouwehand WH, Palmer DS, Paunio T, Quested D, Rapaport MH, Rees E, Rollins B, Satterstrom FK, Schatzberg A, Scolnick E, Scott LJ, Sharp SI, Sklar P, Smoller JW, Sobell JL, Solomonson M, Stahl EA, Stevens CR, Suvisaari J, Tiao G, Watson SJ, Watts NA, Blackwood DH, Børglum AD, Cohen BM, Corvin AP, Esko T, Freimer NB, Glatt SJ, Hultman CM, McQuillin A, Palotie A, Pato CN, Pato MT, Pulver AE, St Clair D, Tsuang MT, Vawter MP, Walters JT, Werge TM, Ophoff RA, Sullivan PF, Owen MJ, Boehnke M, O'Donovan MC, Neale BM, Daly MJ
Nature. 2022; 604(7906):509-516. - Identification of potential blood biomarkers associated with suicide in major depressive disorder
Mamdani F, Weber MD, Bunney B, Burke K, Cartagena P, Walsh D, Lee FS, Barchas J, Schatzberg AF, Myers RM, Watson SJ, Akil H, Vawter MP, Bunney WE, Sequeira A
Transl Psychiatry. 2022; 12(1):159. - Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model
Maras PM, Hebda-Bauer EK, Hagenauer MH, Hilde KL, Blandino P Jr, Watson SJ Jr, Akil H
Transl Psychiatry. 2022; 12(1):105. - Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress
Murra D, Hilde KL, Fitzpatrick A, Maras PM, Watson SJ, Akil H
Neurobiol Stress. 2022; 17:100437. - Long-term effects of intermittent early life stress on primate prefrontal-subcortical functional connectivity
Yuan R, Nechvatal JM, Buckmaster CL, Ayash S, Parker KJ, Schatzberg AF, Lyons DM, Menon V
Neuropsychopharmacology. 2021; 46(7):1348-1356. - Accelerated brain aging predicts impulsivity and symptom severity in depression
Dunlop K, Victoria LW, Downar J, Gunning FM, Liston C
Neuropsychopharmacology. 2021; 46(5):911-919. - Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics
Buch AM, Liston C
Neuropsychopharmacology. 2021; 46(1):156-175. - Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring
Spellman T, Svei M, Kaminsky J, Manzano-Nieves G, Liston C
Cell. 2021; 184(10):2750-2766.e17. - Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human
Li A, Jing D, Dellarco DV, Hall BS, Yang R, Heilberg RT, Huang C, Liston C, Casey BJ, Lee FS
Mol Psychiatry. 2021; 26(3):955-973. - Pre-adolescent stress disrupts adult, but not adolescent, safety learning
Meyer HC, Gerhard DM, Amelio PA, Lee FS
Behav Brain Res. 2021; 400:113005. - Optimization and evaluation of fluorescence in situ hybridization chain reaction in cleared fresh-frozen brain tissues
Kumar V, Krolewski DM, Hebda-Bauer EK, Parsegian A, Martin B, Foltz M, Akil H, Watson SJ
Brain Struct Funct. 2021; 226(2):481-499. - Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One?
Weston RG, Fitzgerald PJ, Watson BO
Front Psychiatry. 2021; 12:659052. - Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test
Fitzgerald PJ, Hale PH, Ghimire A, Watson BO
Behav Brain Res. 2021; 409:113323. - Incident Major Depressive Disorder Predicted by Three Measures of Insulin Resistance: A Dutch Cohort Study
Watson KT, Simard JF, Henderson VW, Nutkiewicz L, Lamers F, Nasca C, Rasgon N, Penninx BWJH
Am J Psychiatry. 2021; 178(10):914-920. - An adolescent sensitive period for threat responding: impacts of stress and sex
Gerhard DM, Meyer HC, Lee FS
Biol Psychiatry. 2021; 89(7):651-658. - Accelerated brain aging predicts impulsivity and symptom severity in depression
Dunlop K, Victoria LW, Downar J, Gunning FM, Liston C
Neuropsychopharmacology. 2021; 46(5):911-919. - Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human
Li A, Jing DQ, Dellarco DV, Hall BS, Yang R, Heilberg RT, Huang C, Liston C, Casey BJ, Lee FS
Mol Psychiatry. 2021; 26(3):955-973. - Optimization and evaluation of fluorescence in situ hybridization chain reaction in cleared fresh-frozen brain tissues
Kumar V, Krolewski DM, Hebda-Bauer EK, Parsegian A, Martin B, Foltz M, Akil H, Watson SJ Jr
Brain Struct Funct. 2021; 226(2):481-499. - Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model
Birt IA, Hagenauer MH, Clinton SM, Aydin C, Blandino P Jr, Stead JDH, Hilde KL, Meng F, Thompson RC, Khalil H, Stefanov A, Maras P, Zhou Z, Hebda-Bauer EK, Goldman D, Watson SJ Jr, Akil H
Biol Psychiatry. 2021; 89(4):339-355. - Long-term effects of intermittent early life stress on primate prefrontal-subcortical functional connectivity
Yuan R, Nechvatal JM, Buckmaster CL, Ayash S, Parker KJ, Schatzberg AF, Lyons DM, Menon V
Neuropsychopharmacology. 2021; Online ahead of print. - Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring
Spellman T, Svei M, Kaminsky J, Manzano-Nieves G, Liston C
Biorxiv. 2021; Online ahead of print. - Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics
Buch A, Liston C
Neuropsychopharmacology. 2021; 46(1):156-175. - The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test
Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO
Transl Psychiatry. 2020; 10(1):255. - The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
Coleman JRI, Gaspar HA, Bryois J
Biol Psychiatry. 2020; 88(2):169-184. - Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach
Emery MA, Akil H
Annu Rev Neurosci. 2020; 43:355-374. - Causes and Consequences of Diagnostic Heterogeneity in Depression: Paths to Discovering Novel Biological Depression Subtypes
Lynch CJ, Liston C
Biol Psychiatry. 2020; 88(1):83-94. - Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction
Spencer-Segal JL, Singer BH, Laborc K, Somayaji K, Watson SJ, Standiford TJ, Akil H
Psychoneuroendocrinology. 2020; 117:104679. - Toward Circuit Mechanisms of Pathophysiology in Depression
Spellman T, Liston C
Am J Psychiatry. 2020; 177(5):381-390. - Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice
Burgdorf CE, Jing DQ, Yang R, Huang C, Hill MN, Mackie K, Milner TA, Pickel VM, Lee FS, Rajadhyaksha AM
Sci Adv. 2020; 6(7):eaay1502. - Blockade of the cholecystokinin CCK-2 receptor prevents the normalization of anxiety levels in the rat
Ballaz SJ, Bourin M, Akil H, Watson SJ
Prog Neuropsychopharmacol Biol Psychiatry. 2020; 97:109761. - Revisiting the stress concept: Implications for affective disorders
McEwen BS, Akil H
J Neurosci. 2020; 40(1):12-21. - Multisensory modulation of body ownership in mice
Buckmaster CL, Rathmann-Bloch JE, de Lecea L, Schatzberg AF, Lyons DM
Neurosci Conscious. 2020; 2020(1):niz019. - Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
Meyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG
Proc Natl Acad Sci U S A. 2019:pii: 201910481. - HPA axis in psychotic major depression and schizophrenia spectrum disorders: Cortisol, clinical symptomatology, and cognition
Cherian K, Schatzberg AF, Keller J
Schizophr Res. 2019; 213:72-79. - Association of myoinositol transporters with schizophrenia and bipolar disorder: Evidence from human and animal studies
Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A
Mol Neuropsychiatry. 2019; 5(4):200-211. - Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors
Limon A, Delbruck E, Yassine A, Pandya D, Myers RM, Barchas JD, Lee F, Schatzberg, Watson SJ, Akil H, Bunney WE, Vawter MP, Sequeira A
Transl Psychiatry. 2019; 9(1):218. - Adaptation to single housing is dynamic: Changes in hormone levels, gene expression, signaling in the brain, and anxiety-like behavior in adult male C57Bl/6J mice
Hebda-Bauer EK, Dokas LA, Watson SJ, Akil H
Horm Behav. 2019; 114:104541. - Effects of early-life FGF2 on ultrasonic vocalizations (USVs) and the mu-opioid receptor in male Sprague-Dawley rats selectively-bred for differences in their response to novelty
Turner CA, Hagenauer MH, Aurbach EL, Maras PM, Fournier CL, Blandino P, Chauhan RB, Panksepp J, Watson SJ, Akil H
Brain Res. 2019; 1715:106-114. - Modeling the daily rhythm of human pain processing in the dorsal horn
Crodelle J, Pilz S, Hagenauer MH, Booth V
PLoS Comput Biol. 2019; 15(7):e1007106. - Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders
Hjelm BE, Rollins B, Morgan L, Sequeira A, Mamdani F, Pereira F, Damas J, Webb MG, Weber MD, Schatzberg AF, Barchas JD, Lee FS, Akil H, Watson SJ, Myers RM, Chao EC, Kimonis V, Thompson PM, Bunney WE, Vawter MP
Nucleic Acids Res. 2019; 47(10):e59. - Genome-wide association study identifies 30 loci associated with bipolar disorder
Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A, Antilla V, Awasthi S, Badner JA, Bækvad-Hansen M, Barchas JD, Bass N, Bauer M, Belliveau R, Bergen SE, Pedersen CB, Bøen E, Boks MP, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Casas M, Cerrato F, Cervantes P, Chambert K, Charney AW, Chen D, Churchhouse C, Clarke TK, Coryell W, Craig DW, Cruceanu C, Curtis D, Czerski PM, Dale AM, de Jong S, Degenhardt F, Del-Favero J, DePaulo JR, Djurovic S, Dobbyn AL, Dumont A, Elvsåshagen T, Escott-Price V, Fan CC, Fischer SB, Flickinger M, Foroud TM, Forty L, Frank J, Fraser C, Freimer NB, Frisén L, Gade K, Gage D, Garnham J, Giambartolomei C, Pedersen MG, Goldstein J, Gordon SD, Gordon-Smith K, Green EK, Green MJ, Greenwood TA, Grove J, Guan W, Guzman-Parra J, Hamshere ML, Hautzinger M, Heilbronner U, Herms S, Hipolito M, Hoffmann P, Holland D, Huckins L, Jamain S, Johnson JS, Juréus A, Kandaswamy R, Karlsson R, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koller AC, Kupka R, Lavebratt C, Lawrence J, Lawson WB, Leber M, Lee PH, Levy SE, Li JZ, Liu C, Lucae S, Maaser A, MacIntyre DJ, Mahon PB, Maier W, Martinsson L, McCarroll S, McGuffin P, McInnis MG, McKay JD, Medeiros H, Medland SE, Meng F, Milani L, Montgomery GW, Morris DW, Mühleisen TW, Mullins N, Nguyen H, Nievergelt CM, Adolfsson AN, Nwulia EA, O'Donovan C, Loohuis LMO, Ori APS, Oruc L, Ösby U, Perlis RH, Perry A, Pfennig A, Potash JB, Purcell SM, Regeer EJ, Reif A, Reinbold CS, Rice JP, Rivas F, Rivera M, Roussos P, Ruderfer DM, Ryu E, Sánchez-Mora C, Schatzberg AF, Scheftner WA, Schork NJ, Shannon Weickert C, Shehktman T, Shilling PD, Sigurdsson E, Slaney C, Smeland OB, Sobell JL, Søholm Hansen C, Spijker AT, St Clair D, Steffens M, Strauss JS, Streit F, Strohmaier J, Szelinger S, Thompson RC, Thorgeirsson TE, Treutlein J, Vedder H, Wang W, Watson SJ, Weickert TW, Witt SH, Xi S, Xu W, Young AH, Zandi P, Zhang P, Zöllner S; eQTLGen Consortium; BIOS Consortium, Adolfsson R, Agartz I, Alda M, Backlund L, Baune BT, Bellivier F, Berrettini WH, Biernacka JM, Blackwood DHR, Boehnke M, Børglum AD, Corvin A, Craddock N, Daly MJ, Dannlowski U, Esko T, Etain B, Frye M, Fullerton JM, Gershon ES, Gill M, Goes F, Grigoroiu-Serbanescu M, Hauser J, Hougaard DM, Hultman CM, Jones I, Jones LA, Kahn RS, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Martin NG, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Metspalu A, Mitchell PB, Morken G, Mors O, Mortensen PB, Müller-Myhsok B, Myers RM, Neale BM, Nimgaonkar V, Nordentoft M, Nöthen MM, O'Donovan MC, Oedegaard KJ, Owen MJ, Paciga SA, Pato C, Pato MT, Posthuma D, Ramos-Quiroga JA, Ribasés M, Rietschel M, Rouleau GA, Schalling M, Schofield PR, Schulze TG, Serretti A, Smoller JW, Stefansson H, Stefansson K, Stordal E, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Werge T, Nurnberger JI, Wray NR, Di Florio A, Edenberg HJ, Cichon S, Ophoff RA, Scott LJ, Andreassen OA, Kelsoe J, Sklar P; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Nat Genet. 2019; 51(5):793-803. - Glucocorticoids and resilience
Spencer-Segal JL, Akil H
Horm Behav. 2019; 111:131-134. - Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human
Li A, Jing D, Dellarco DV, Hall BS, Yang R, Heilberg RT, Huang C, Liston C, Casey BJ, Lee FS
Mol Psychiatry. 2019. - Translating developmental neuroscience to understand risk for psychiatric sisorders
Meyer HC, Lee FS
Am J Psychiatry. 2019; 176(3):179-185. - Novel complex interactions between mitochondrial and nuclear DNA in schizophrenia and bipolar disorder
Schulmann A, Ryu E, Goncalves V, Rollins B, Christiansen M, Frye MA, Biernacka J, Vawter MP
Mol Neuropsychiatry. 2019; 5(1):13-27. - Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates
Turner CA, Lyons DM, Buckmaster CL, Aurbach EL, Watson SJ Jr, Schatzberg AF, Akil H
Neuropsychopharmacology. 2019; 44(2):356-363. - Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium
Cell. 2018; 173(7):1705-1715. - Learning to actively cope with stress in female mice
Lyons DM, Buckmaster CL, Schatzberg AF
Psychoneuroendocrinology. 2018; 96:78-83. - Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
Williams NR, Heifets BD, Blasey C, Sudheimer K, Pannu J, Pankow H, Hawkins J, Birnbaum J, Lyons DM, Rodriguez CI, Schatzberg AF
Am J Psychiatry. 2018; appiajp201818020138. - Fibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons
Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M
J Neurochem. 2018; 145(3):188-203. - Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding
Wei Q, Krolewski DM, Moore S, Kumar V, Li F, Martin B, Tomer R, Murphy GG, Deisseroth K, Watson SJ Jr, Akil H
Proc Natl Acad Sci U S A. 2018; 115(40):E9489-E9498. - Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis
Hagenauer MH, Schulmann A, Li JZ, Vawter MP, Walsh DM, Thompson RC, Turner CA, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ Jr, Akil H
PLoS One. 2018; 13(7):e0200003. - Connective tissue growth factor Is a novel prodepressant
Turner CA, Sharma V, Hagenauer MH, Chaudhury S, O'Connor AM, Hebda-Bauer EK, Thompson RC, Myers RM, Bunney WE, Barchas JD, Lee FS, Schatzberg AF, Watson SJ Jr, Akil H
Biol Psychiatry. 2018; 84(8):555-562. - Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations
Krolewski DM, Kumar V, Martin B, Tomer R, Deisseroth K, Myers RM, Schatzberg AF, Lee FS, Barchas JD, Bunney WE, Akil H, Watson SJ Jr
Brain Struct Funct. 2018; 223(2):987-999. - The BDNF Val66Met prodomain disassembles dendritic spines altering fear extinction circuitry and behavior
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Neuron. 2018; 99:163-178. - Acetyl-l-carnitine deficiency in patients with major depressive disorder
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Proc Natl Acad Sci U S A. 2018; 115(34):8627-8632. - Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance
Balsevich G, Sticht M, Bowles NP, Singh A, Lee TT, Li Z, Chelikani PK, Lee FS, Borgland SL, Hillard CJ, McEwen BS, Hill MN
Proc Natl Acad Sci U S A. 2018; 115(29):7605-7610. - Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice
Gray JD, Rubin TG, Kogan JF, Marrocco J, Weidmann J, Lindkvist S, Lee FS, Schmidt EF, McEwen BS
Mol Psychiatry. 2018; 23(4):904-913. - Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence
Rollins BL, Morgan L, Hjelm BE, Sequeira A, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP
Mol Neuropsychiatry. 2018; 3(3):157-169. - Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression
Davis EG, Keller J, Hallmayer J, Pankow HR, Murphy GM Jr., Gotlib IH, Schatzberg AF
Transl Psychiatry. 2018; 8(1):5. - Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response
Block TS, Kushner H, Kalin N, Nelson C, Belanoff J, Schatzberg A
Biol Psychiatry. 2018; pii: S0006-3223(18):30035-0. - The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG
Neuropsychopharmacology. 2018; 43(1):21-33. - Utilizing a unique animal model to better understand human temperament
Turner CA, Flagel SB, Blandino P Jr, Watson SJ Jr, Akil H
Curr Opin Behav Sci. 2017; 14:108-114. - Stress amplifies sex differences in primate prefrontal profiles of gene expression
Lee AG, Hagenauer M, Absher D, Morrison KE, Bale TL, Myers RM, Watson SJ, Akil H, Schatzberg AF, Lyons DM
Biol Sex Differ. 2017; 8(1):36. - Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice
Zhou Y, Schwartz BI, Giza J, Gross SS, Lee FS, Kreek MJ
Psychopharmacology (Berl). 2017; 234(19):2955-70. - Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice
Dincheva I, Yang J, Li A, Marinic T, Freilingsdorf H, Huang C, Casey BJ, Hempstead B, Glatt CE, Lee FS, Bath KG, Jing D
Am J Psychiatry. 2017; 174(12):1203-13. - Post-mortem molecular profiling of three psychiatric disorders
Ramaker RC, Bowling KM, Lasseigne BN, Hagenauer MH, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG, Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, Akil H, Bunney WE, Li JZ, Cooper SJ, Myers RM
Genome Med. 2017; 9(1):72. - Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder
Song M, Mathews CA, Stewart SE, Shmelkov SV, Mezey JG, Rodriguez-Flores JL, Rasmussen SA, Britton JC, Oh YS, Walkup JT, Lee FS, Glatt CE
PLoS One. 2017; 12(1):e0169994. - Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life
Prater KE, Aurbach EL, Larcinese HK, Smith TN, Turner CA, Blandino P, Watson SJ, Maren S, Akil H
Neuropsychopharmacology. 2017; Epub ahead of print. - Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories
Pattwell SS, Liston C, Jing D, Ninan I, Yang RR, Witztum J, Murdock MH, Dincheva I, Bath KG, Casey BJ, Deisseroth K, Lee FS
Nat Commun. 2016; 7:11475. - Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice
Gray JD, Rubin TG, Kogan JF, Marrocco J, Weidmann J, Lindkvist S, Lee FS, Schmidt EF, McEwen BS
Mol Psychiatry. 2016; Epub ahead of print. - Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice
Lee AG, Capanzana R, Brockhurst J, Cheng MY, Buckmaster CL, Absher D, Schatzberg AF, Lyons DM
Neurobiol Learn Mem. 2016; 131:95-100. - Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder
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Transl Psychiatry. 2016; 6:e810. - HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition
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Mol Psychiatry. 2016; Epub ahead of print. - Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders
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Semin Cell Dev Biol. 2016; 53:136-43. - Fibroblast Growth Factor 2 Sits at the Interface of Stress and Anxiety
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Biol Psychiatry. 2016; 80(6):419-21. - Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders
Morgan LZ, Rollins B, Sequeira A, Byerley W, DeLisi LE, Schatzberg AF, Barchas JD, Myers RM, Watson SJ, Akil H, Bunney WE, Vawter MP
Microarrays (Basel). 2016; 5(1). - Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups
Litvin Y, Turner CA, Rios MB, Maras PM, Chaudhury S, Baker MR, Blandino P Jr, Watson SJ Jr, Akil H, McEwen B
Horm Behav. 2016; 86:64-70. - The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression
Azevedo JA, Carter BS, Meng F, Turner DL, Dai M, Schatzberg AF, Barchas JD, Jones EG, Bunney WE, Myers RM, Akil H, Watson SJ, Thompson RC
J Psychiatr Res. 2016; 82:58-67. - NMDA antagonist treatment of depression
Williams NR, Schatzberg AF
Curr Opin Neurobiol. 2016; 36:112-117. - Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation
Glatt CE, Lee FS
Biol Psychiatry. 2016; 79(1):25-31. - Evidence for alterations of the glial syncytial function in major depressive disorder
Medina A, Watson SJ, Bunney W Jr, Myers RM, Schatzberg A, Barchas J, Akil H, Thompson RC
J Psychiatr Res. 2016; 72:15-21. - Cup tool use by squirrel monkeys
Buckmaster CL, Hyde SA, Parker KJ, Lyons DM
Am J Primatol. 2015; 77(12):1323-32. - Opioids in Psychiatric Disorders: Back to the Future?
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Am J Psychiatry. 2015; Epub ahead of print. - Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders
Turner CA, Eren-Koçak E, Inui EG, Watson SJ, Akil H
Semin Cell Dev Biol. 2015:pii: S1084-9521(15)00188-3. - Fibroblast growth factor 9 is a novel modulator of negative affect
Aurbach EL, Inui EG, Turner CA, Hagenauer MH, Prater KE, Li JZ, Absher D, Shah N, Blandino P Jr, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ Jr, Akil H
Proc Natl Acad Sci U S A. 2015; 112(38):11953-8. - Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
Mamdani F, Rollins B, Morgan L, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP, Sequeira PA
Transl Psychiatry. 2015; 5:e636. - Development of New Psychopharmacological Agents for Depression and Anxiety
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Psychiatr Clin North Am. 2015; 38(3):379-93. - Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling
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Dev Cell. 2015; 33(6):690-702. - Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies
Casey BJ, Glatt CE, Lee FS
Neuron. 2015; 86(6):1358-68. - Mitochondrial mutations in subjects with psychiatric disorders
Sequeira A, Rollins B, Magnan C, van Oven M, Baldi P, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Vawter MP
PLoS One. 2015; 10(5):e0127280. - Perspectives on depression--past, present, future(a)
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Ann N Y Acad Sci. 2015; 1345:1-15. - Stress inoculation modeled in mice
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Transl Psychiatry. 2015; 5:e537. - FAAH genetic variation enhances fronto-amygdala function in mouse and human
Dincheva I, Drysdale AT, Hartley CA, Johnson DC, Jing D, King EC, Ra S, Gray JM, Yang R, DeGruccio AM, Huang C, Cravatt BF, Glatt CE, Hill MN, Casey BJ, Lee FS
Nat Commun. 2015; 6:6395. - Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells
Huang HS, Redmond TM, Kubish GM, Gupta S, Thompson RC, Turner DL, Uhler MD
J Mol Neurosci. 2015; 55(3):684-705. - Decreased hypothalamic functional connectivity with subgenual cortex in psychotic major depression
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Neuropsychopharmacology. 2015; 40(4):849-60. - Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
Mamdani F, Rollins B, Morgan L, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP, Sequeira PA
Transl Psychiatry. 2015; 5:e636. - Fibroblast growth factor 9 is a novel modulator of negative affect
Aurbach EL, Inui EG, Turner CA, Hagenauer MH, Prater KE, Li JZ, Absher DM, Shah N, Blandino P Jr, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H
Proc Natl Acad Sci U S A. 2015. - The chicken and egg of anxiety and depression
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Epidemiol Psychiatr Sci. 2015; 24(3):227-9. - Mitochondrial mutations in subjects with psychiatric disorders
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PLoS One. 2015; 10(5):e0127280. - Issues encountered in recent attempts to develop novel antidepressant agents
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Ann N Y Acad Sci. 2015; 1345(1):67-73. - Perspectives on depression-past, present, futurea
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Ann N Y Acad Sci. 2015; 1345(1):1-15. - Stress inoculation modeled in mice
Brockhurst J, Cheleuitte-Nieves C, Buckmaster CL, Schatzberg AF, Lyons DM
Transl Psychiatry. 2015; 5:e537. - Decreased hypothalamic functional connectivity with subgenual cortex in psychotic major depression
Sudheimer K, Keller J, Gomez R, Tennakoon L, Reiss A, Garrett A, Kenna H, O'Hara R, Schatzberg AF
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Bunney BG, Li JZ, Walsh DM, Stein R, Vawter MP, Cartagena P, Barchas JD, Schatzberg AF, Myers RM, Watson SJ, Akil H, Bunney WE
Mol Psychiatry. 2015; 20(1):48-55. - Anna-Monika Award Lecture, DGPPN Kongress, 2013: the role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression
Schatzberg AF
World J Biol Psychiatry. 2015; 16(1):2-11. - Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?
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Neuropsychopharmacology. 2015; 40(2):259-67. - ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression
Ray A, Tennakoon L, Keller J, Sarginson JE, Ryan HS, Murphy GM, Lazzeroni LC, Trivedi MH, Kocsis JH, DeBattista C, Schatzberg AF
Pharmacogenomics J. 2014; Epub ahead of print. - An overview of vortioxetine
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J Clin Psychiatry. 2014; 75(12):1411-8. - Coping and glucocorticoid receptor regulation by stress inoculation
Lee AG, Buckmaster CL, Yi E, Schatzberg AF, Lyons DM
Psychoneuroendocrinology. 2014; 49:272-9. - FGF2 is a target and a trigger of epigenetic mechanisms associated with differences in emotionality: partnership with H3K9me3
Chaudhury S, Aurbach EL, Sharma V, Blandino P Jr, Turner CA, Watson SJ, Akil H
Proc Natl Acad Sci U S A. 2014; 111(32):11834-9. - Fully automated high-throughput chromatin immunoprecipitation for ChIP-seq: identifying ChIP-quality p300 monoclonal antibodies
Gasper WC, Marinov GK, Pauli-Behn F, Scott MT, Newberry K, DeSalvo G, Ou S, Myers RM, Vielmetter J, Wold BJ
Sci Rep. 2014; 4:5152. - A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan-Lottick NS
Cancer. 2014; 120(9):1417-25. - Defining functional DNA elements in the human genome
Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos JA, Weng Z, White KP, Hardison RC
Proc Natl Acad Sci U S A. 2014; 111(17):6131-8. - Altered choroid plexus gene expression in major depressive disorder
Turner CA, Thompson RC, Bunney WE, Schatzberg AF, Barchas JD, Myers RM, Akil H, Watson SJ
Front Hum Neurosci. 2014; 8:238. - Basal microRNA expression patterns in reward circuitry of selectively bred high-responder and low-responder rats vary by brain region and genotype
Hamilton DE, Cooke CL, Carter BS, Akil H, Watson SJ, Thompson RC
Physiol Genomics. 2014; 46(8):290-301. - Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol
Yuen KW, Garner JP, Carson DS, Keller J, Lembke A, Hyde SA, Kenna HA, Tennakoon L, Schatzberg AF, Parker KJ
J Psychiatr Res. 2014; 51:30-6. - From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing
Marinov GK, Williams BA, McCue K, Schroth GP, Gertz J, Myers RM, Wold BJ
Genome Res. 2014; 24(3):496-510. - HPA axis genetic variation, cortisol and psychosis in major depression
Schatzberg AF, Keller J, Tennakoon L, Lembke A, Williams G, Kraemer FB, Sarginson JE, Lazzeroni LC, Murphy GM
Mol Psychiatry. 2014; 19(2):220-7. - High novelty-seeking rats are resilient to negative physiological effects of the early life stress
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Stress. 2014; 17(1):97-107. - Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P; The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups; The International Multiple Sclerosis Genetics Consortium (IMSGC), McEvoy LK, Desikan RS, Lie BA, Djurovic S, Dale AM
Mol Psychiatry. 2014; Epub ahead of print. - A Time for Every Purpose: Biological Clocks and Animal Behavior
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Animal Behavior. 2014; 338(6114):1569-75. - Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty
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Neuropharmacology. 2014; 76 Pt B:425-36. - Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex
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Schizophr Res. 2014; 152(1):111-6. - Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience
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Bioessays. 2014; 36(3):305-15. - Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
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Nat Genet. 2013; 45(9):984-94. - Conversion of short-term to long-term memory in the novel object recognition paradigm
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Neurobiol Learn Mem. 2013; 105:174-85. - Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder
Medina A, Burke S, Thompson RC, Bunney WE, Myers RM, Schatzberg A, Akil H, Watson SJ
J Psychiatr Res. 2013; 47(9):1150-6. - Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
Guella I, Sequeira A, Rollins B, Morgan L, Torri F, van Erp TG, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Potkin SG, Macciardi F, Vawter MP
J Psychiatr Res. 2013; 47(9):1215-21. - Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality
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Neuroscience. 2013; 248C:436-47. - Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats
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Neuroscience. 2013; 248C:571-584. - Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats
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Neuroscience. 2013; 255:68-75. - G protein-linked signaling pathways in bipolar and major depressive disorders
Tomita H, Ziegler ME, Kim HB, Evans SJ, Choudary PV, Li JZ, Meng F, Dai M, Myers RM, Neal CR, Speed TP, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Jones EG, Bunney WE, Vawter MP
Front Genet. 2013; 4:297. - Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ, Akil H, Bunney WE
PNAS. 2013; 110(24):9950-5. - The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary-adrenal activity in humans with psychotic major depression
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Neurosci Res. 2013; Epub ahead of print. - Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder
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J Psychiatr Res. 2013; 47(3):307-14. - Inborn differences in environmental reactivity predict divergent diurnal behavioral, endocrine, and gene expression rhythms
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Psychoneuroendocrinology. 2012; 37(2):256-69. - 3xTg-AD Mice Exhibit an Activated Central Stress Axis During Early-Stage Pathology
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J Alzheimers Dis. 2012; 33(2):407-22. - Early-life forebrain glucocorticoid receptor overexpression increases anxiety behavior and cocaine sensitization
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Biol Psychiatry. 2012; 71(3):224-31. - Individual differences in the improvement of cocaine-induced place preference response by the 5-HT(2C) receptor antagonist SB242084 in rats.
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Psychopharmacology (Berl). 2012; 220(4):731-40. - The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior
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Eur Neuropsychopharmacol. 2012; 22(8):607-13. - DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats
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Dev Neurosci. 2012; 34(1):58-67. - The fibroblast growth factor family: neuromodulation of affective behavior
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Neuron. 2012; 76(1):160-74. - Neonatal fibroblast growth factor treatment enhances cocaine sensitization
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Pharmacol Biochem Behav. 2012; 103(1):6-17. - Fibroblast growth factor-2: an endogenous antidepressant and anxiolytic molecule?
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Biol Psychiatry. 2012; 72(4):254-5. - Treating the developing brain: implications from human imaging and mouse genetics
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Annual Review of Medicine. 2012; 64. - Altered fear learning across development in both mouse and human
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Neuroscience. 2011; 196:80-96. - Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter
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Trends Neurosci. 2011; 34(3):143-53. - Selective early-acquired fear memories undergo temporary suppression during adolescence
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Horm Behav. 2010; 58(3):355-67. - The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus
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Proceedings of BioLink 2007: Linking Literature, Information and Knowledge for Biology. 2007. - An Active Visual Search Interface for Medline
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Lecture Notes in Computer Science. 2007; 4394:186-195. - Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome
Buck, B. J.; Kerman, I. A.; Burghardt, P. R.; Koch, L. G.; Britton, S. L.; Akil, H.
Neuroscience Letters. 2007; 419(2):178-183. - Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition
MP Vawter; PD Harvey; LE DeLisi
Am J Med Genet B Neuropsychiatr Genet. 2007; 144B(6):728-34. - NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences.
ME Atz; B Rollins; MP Vawter
Psychiatr Genet. 2007; 17(2):55-67. - Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice.
AM Rozeboom; H Akil; AF Seasholtz
Proc Natl Acad Sci. 2007; 104(11):4688-4693. - Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder.
SA Langenecker; SE Kennedy; LM Guidotti; EM Briceno; LS Own; T Hooven; EA Young; H Akil; DC Noll; JK Zubieta
Biol Psychiatry. 2007; 62(11):1272-1280. - A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test.
SA Langenecker; JK Zubieta; EA Young; H Akil; KA Nielson
J Clin Exp Neuropsychol. 2007; 29(8):842-853. - Current issues in the classification of psychotic major depression
J. Keller; A. F. Schatzberg; M. Maj
Schizophr Bull. 2007; 33(4):887-885. - Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction.
Q Wei; Hebda-Bauer EK; A Pletsch; J Luo; MT Hoversten; AJ Osetek; SJ Evans; SJ Watson; AF Seasholtz; H Akil
J Neurosci. 2007; 27(33):8836-8844. - Sample matching by inferred agonal stress in gene expression analyses of brain.
JZ Li; F Meng; L Tsavaler; SJ Evans; PV Choudary; H Tomita; MP Vawter; D Walsh; V Shokoohi; T Chung; WE Bunney; EG Jones; H Akil; SJ Watson; RM Myers
BMC Genomics. 2007; 8(336). - Medline Search Engine for Finding Potential Biological Significance of Genetic Markers
W. Xuan; P. Wang; S. J. Watson; F. Meng
Bioinformatics. 2007; 23(18):2477-2484. - Stress-induced changes in primate prefrontal profiles of gene expression.
AM Karssen; S Her; JZ Li; PD Patel; F Meng; Bunney WE Jr; EG Jones; SJ Watson; H Akil; RM Myers; AF Schatzberg; DM Lyons
Mol Psychiatry. 2007; 12(12):1089-1102. - Previous experience affects subsequent anxiety-like responses in rats bred for novelty seeking.
SJ Ballaz; H Akil; SJ Watson
Behav Neurosci. 2007; 121(5):1113-1118. - Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentration hormone in the rat lateral hypothalamus.
IA Kerman; R Bernard; D Rosenthal; J Beals; H Akil; SJ Watson
J Comp Neurol. 2007; 505(5):586-601. - The CCK-system mediates adaptation to novelty-induced stress in the rat: a pharmacological evidence.
SJ Ballaz; H Akil; SJ Watson
Neurosci Lett. 2007; 428(1):27-32. - Stress inoculation-induced indications of resilience in monkeys
D. M. Lyons; K. J. Parker
J Trauma Stress. 2007; 20(4):423-433. - Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males.
Hebda-Bauer EK; J Luo; SJ Watson; H Akil
Neuroscience. 2007; 150(2):260-272. - Early life stress and novelty seeking behavior in adolescent monkeys
K. J. Parker; K. L. Rainwater; C. L. Buckmaster; A. F. Schatzberg; S. E. Lindley; D. M. Lyons
Psychoneuroendocrinology. 2007; 32(7):785-792. - Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone
T. M. Buckley; B. C. Mullen; A. F. Schatzberg
Biol Psychiatry. 2007; 62(10):1171-1174. - The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls
T. M. Buckley; B. C. Mullen; A. F. Schatzberg
Psychoneuroendocrinology. 2007; 32(8-10):859-864. - Rostral Elements of Sympatho-motor Circuitry: A Virally Mediated Transsynaptic Tracing Study
Kerman, Ilan A.; Akil, Huda; Watson, Stanley J.
The Journal of Neuroscience. 2006; 26(13):3423-3433. - SNPs on Chips: The Hidden Genetic Code in Expression Arrays
Sliwerska, Elzbieta; Meng, Fan; Speed, Terence P.; Jones, Edward G.; Bunney, William E.; Akil, Huda; Watson, Stanley J.; Burmeister, Margit
Biological Psychiatry. 2006; 61(1):13-16. - Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
Vawter, M P; Tomita, H; Meng, F; Bolstad, B; Li, J; Evans, S; Choudary, P; Atz, M; Shao, L; Neal, C; Walsh, D M; Burmeister, M; Speed, T; Myers, R; Jones, E G; Watson, S J; Akil, H; Bunney, W E
Molecular Psychiatry. 2006; 11(7):615, 663-79. - The Fibroblast Growth Factor System and Mood Disorders
Turner, Cortney A.; Akil, Huda; Watson, Stanley J.; Evans, Simon J.
Biological Psychiatry. 2006; 59(12):1128-1135. - Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem
Kerman, I. A.; Shabrang, C.; Taylor, L.; Akil, H.; Watson, S. J.
Journal of Comparative Neurology. 2006; 499(6):882-896. - Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia
MP Vawter; ME Atz; BL Rollins; Cooper-Casey KM; L Shao; WF Byerley
Hum Genet. 2006; 119(5):558-70. - Transcriptional profiling of the developing rat brain reveals that the most dramatic regional differentiation in gene expression occurs postpartum.
JD Stead; C Neal; F Meng; Y Wang; S Evans; DM Vazquez; SJ Watson; H Akil
J Neurosci. 2006; 26(1):345-353. - Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.
JD Stead; S Clinton; C Neal; J Schneider; A Jama; S Miller; DM Vazquez; SJ Watson; H Akil
Behav Genet. 2006; 36(5):697-712. - Social stress-related behavior affects hippocampal cell proliferation in mice
R. Mitra; K. Sundlass; K. J. Parker; A. F. Schatzberg; D. M. Lyons
Physiol Behav. 2006; 89(2):123-127. - Cortisol circadian rhythm alterations in psychotic major depression
J. Keller; B. Flores; R. G. Gomez; H. B. Solvason; H. Kenna; G. H. Williams; A. F. Schatzberg
Biol Psychiatry. 2006; 60(3):275-281. - Combining laser capture microdissection with quantitatitve real-time PCR: effects of tissue manipulation on RNA quality and gene expression.
IA Kerman; BJ Buck; SJ Evans; H Akil; SJ Watson
J Neurosci Methods. 2006; 153(1):71-85. - The neuropsychological profile of psychotic major depression and its relation to cortisol
R. G. Gomez; S. H. Fleming; J. Keller; B. Flores; H. Kenna; C. DeBattista; B. Solvason; A. F. Schatzberg
Biol Psychiatry. 2006; 60(5):472-478. - Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
K. J. Parker; C. L. Buckmaster; K. Sundlass; A. F. Schatzberg; D. M. Lyons
Proc Natl Acad Sci U S A. 2006; 103(8):3000-3005. - Application of microarray technology in primate behavioral neuroscience research
A. M. Karssen; J. Z. Li; S. Her; P. D. Patel; F. Meng; S. J. Evans; M. P. Vawter; H. Tomita; P. V. Choudary; W. E. Bunney; Jr. Jones E. G.; S. J. Watson; H. Akil; R. M. Myers; A. F. Schatzberg; D. M. Lyons
Methods. 2006; 38(3):227-234. - Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, Manhong; Wang, Pinglang; Boyd, Andrew D.; Kostov, Georgi; Athey, Brian; Jones, Edward G.; Bunney, William E.; Myers, Richard M.; Speed, Terry P.; Akil, Huda; Watson, Stanley J.; Meng, Fan
Nucleic Acids Research. 2005; 33(20):e175. - Gene Definition in Different Databases and Its Implication in Microarray Data Interpretation
Pinglang Wang; Stanley J. Watson; Fan Meng
Advances in Bioinformatics and its Applications Series in Mathematical Biology and Medicine. 2005; 8:62-70. - Exploring Important Issues in The Implementation of Gene Set Enrichment Analysis
Yongjia Wang; Stanley J. Watson; Fan Meng
Advances in Bioinformatics and its Applications Series in Mathematical Biology and Medicine. 2005; 8:71-80. - Screening Potential Alllelle-Frequency Disequilibrium in Data from Affymetrix Gene Expression Arrays
Manhong Dai; Yongjia Wang; Elzbieta Sliwerska; Margit Burmeister; Stanley J. Watson; Huda Akil; Fan Meng
Advances in Bioinformatics and its Applications Series in Mathematical Biology and Medicine. 2005; 8:132-139. - A Database-Linked Diagram Editor for Biological Concepts
Bohua Yu; Manhong Dai; Stanley J. Watson; Fan Meng
Proceedings of The 2005 International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences. 2005:281-286. - Genetical genomics: combining genetics with gene expression analysis
Jun Li; Margit Burmeister
Human Molecular Genetics. 2005; 14(2):R163-R169. - Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V.; Molnar, M.; Evans, S. J.; Tomita, H.; Li, J. Z.; Vawter, M. P.; Myers, R. M.; Bunney,, W. E., Jr.; Akil, H.; Watson, S. J.; Jones, E. G.
PNAS. 2005; 102(43):15653-15658. - GeneInfoMiner--a web server for exploring biomedical literature using batch sequence ID
Weijian Xuan; Stanley J. Watson; Fan Meng
Bioinformatics. 2005; 21(16):3452-3453. - Suggestive linkage of schizophrenia to 5p13 in Costa Rica
K Cooper-Casey; A Me´sen-Fainardi; B Galke-Rollins; M Llach; B Laprade; C Rodriguez; S Riondet; A Bertheau; W Byerley
Molecular Psychiatry. 2005; 10(7):651-656. - Gene expression profile of G protein coupled receptor and related signaling pathways in mood disorder
H. Tomita; S. J. Evans; J. Z. Li; P. V. Choudary; M. P. Vawter; F. Meng; H. Kim; C. R. Neal; D. M. Walsh; M. E. Atz; L. Shao; R. M. Myers; E. G. Jones; S. J. Watson; H. Akil; W. E. Bunney
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2005; 138B(1):4-5. - Stressed and depressed.
Akil, H.
Nat Med. 2005; 11(2):116-118. - On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders
TM Buckley; AF Schatzberg
J Clin Endocrinol Metab. 2005; 90(5):3106-3114. - Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation
TM Buckley; AF Schatzberg
Am J Geriatr Psychiatry. 2005; 13(5):344-352. - Mutations in squirrel monkey glucocorticoid receptor impair nuclear translocation
S. Her; P. D. Patel; A. F. Schatzberg; D. M. Lyons
J Steroid Biochem Mol Biol. 2005; 94(4):319-326. - Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland
Patel, Paresh D.; Pontrello, Crystal; Burke, Sharon
Biological Psychiatry. 2004; 55(4):428-433. - Dysregulation of the fibroblast growth factor system in major depression
Evans, S. J.; Choudary, P. V.; Neal, C. R.; Li, J. Z.; Vawter, M. P.; Tomita, H.; Lopez, J. F.; Thompson, R. C.; Meng, F.; Stead, J. D.; Walsh, D. M.; Myers, R. M.; Bunney, W. E.; Watson, S. J.; Jones, E. G.; Akil, H.
PNAS. 2004; 101(43):15506-15511. - Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
Li, Jun Z.; Vawter, Marquis P.; Walsh, David M.; Tomita, Hiroaki; Evans, Simon J.; Choudary, Prabhakara V.; Lopez, Juan F.; Avelar, Abigail; Shokoohi, Vida; Chung, Tisha; Mesarwi, Omar; Jones, Edward G.; Watson, Stanley J.; Akil, Huda; Bunney, William E., Jr; Myers, Richard M.
Hum. Mol. Genet.. 2004; 13(6):609-616. - Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
Tomita, Hiroaki; Vawter, Marquis P.; Walsh, David M.; Evans, Simon J.; Choudary, Prabhakara V.; Li, Jun; Overman, Kevin M.; Atz, Mary E.; Myers, Richard M.; Jones, Edward G.
Biological Psychiatry. 2004; 55(4):346-352. - Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes
Vawter, Marquis P; Evans, Simon; Choudary, Prabhakara; Tomita, Hiroaki; Meador-Woodruff, Jim; Molnar, Margherita; Li, Jun; Lopez, Juan F; Myers, Rick; Cox, David; Watson, Stanley J; Akil, Huda; Jones, Edward G; Bunney; William E
Neuropsychopharmacology. 2004; 29(2):373-384. - Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional liability.
Q Wei; XY Lu; L Liu; G Schafer; KR Shieh; S Burke; TE Robinson; SJ Watson; AF Seasholtz; H Akil
Proc Natl Acad Sci. 2004; 101(32):11851-11856. - Serotonin 5-HT1A, 5-HT1B, 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
AL Lopez-Figueroa; CS Norton; MO Lopez-Figueroa; D Armellini-Dodel; S Burke; H Akil; JF Lopez; SJ Watson
Biol Psychiatry. 2004; 55(3):225-233. - Untangling genetic networks of panic, phobia, fear and anxiety
Villafuerte, Sandra; Burmeister, Margit
Genome Biology. 2003; 4(8):224. - Evaluation of Sensitivity, Performance and Reproducibility of Microarray Technology in Neuronal Tissue
Evans, S. J.; Watson, S. J.; Akil, H.
Integrative and Comparative Biology. 2003; 43(6):780-785. - Microarray Technology: A Review of New Strategies to Discover Candidate Vulnerability Genes in Psychiatric Disorders
Bunney, William E.; Bunney, Blynn G.; Vawter, Marquis P.; Tomita, Hiroaki; Li, Jun; Evans, Simon J.; Choudary, Prabhakara V.; Myers, Richard M.; Jones, Edward G.; Watson, Stanley J.; Akil, Huda
Am. J. Psychiatry. 2003; 160(4):657-666. - DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
Evans, S. J.; Choudary, P. V.; Vawter, M. P.; Li, J.; Meador-Woodruff, J. H.; Lopez, J. F.; Burke, S. M.; Thompson, R. C.; Myers, R. M.; Jones, E. G.
Neurobiology of Disease. 2003; 14(2):240-250. - MRNA expression patterns and distribution of white matter neurons in dorsolateral prefrontal cortex of depressed patients differ from those in schizophrenia patients
Molnar, Margherita; Potkin, Steven G.; Bunney, Jr., William E.; Jones, Edward G.
Biological Psychiatry. 2003; 53(1):39-47. - Identifying Gene and Protein Names from Biological Texts
W. Xuan; S. J. Watson; H.Akil; F. Meng
IEEE Computer Society Bioinformatics Conference Proceedings. 2003:639-644. - Brainstem substrates of sympatho-motor circuitry identified using trans-synaptic tracing with pseudorabies virus recombinants
Kerman, I. A.; Enquist, L. W.; Watson, S. J.; Yates, B. J.
Journal of Neuroscience. 2003; 23(11):4657-66. - Mineralocorticoid receptor function in major depression.
Elizabeth A. Young; Juan F. Lopez; Virginia Murphy-Weinberg; Stanley J. Watson; Huda Akil
Arch Gen Psychiatry. 2003; 60(1):24-28. - ProbeMatchDB--a web database for finding equivalent probes across microarray platforms and species
P. Wang; F. Ding; H. Chiang; R. C. Thompson; S.J. Watson; F. Meng
Bioinformatics. 2002; 18(3):488-489. - Expression of mRNAs related to the GABAergic and glutamatergic neurotransmitter systems in the human thalamus: normal and schizophrenic
G Popken; MG Leggio; WE Bunney; EG Jones
Thalamus and Related Systems. 2002:349-369. - Hormonal evidence for altered responsiveness to social stress in major depression.
EA Young; JF Lopez; Murphy-Weinberg V; SJ Watson; H Akil
Neuropsychopharmacology. 2000; 23(4):411-418. - The "chip" as a specific genetic tool.
Stanley J. Watson; Fan Meng; Robert C. Thompson; Huda Akil
Biol Psychiatry. 2000; 48(12):1147-1156.